Cover photo

Esophageal Cancer


Hey, Tutti Readers!

We hope you had a blessed Easter if you celebrated it. It's a brand new month, which means it's time to crank up the awesomeness level even higher!

This April, we've got some important causes to champion, including raising awareness for various types of cancer like esophageal cancer. But that's not all – it's also Autism Acceptance Month!

So, let's sprinkle some extra love and kindness everywhere we go, making sure to include everyone in our circle of joy.

Alright, let's kick things off and delve into some key insights about esophageal cancer. Our goal is to explore the most frequently asked questions, providing you with valuable insights into this condition.

  1. What Is Esophageal Cancer?

Esophageal cancer initiates when the cells lining the esophagus undergo uncontrolled growth. The esophagus, a muscular tube facilitating the passage of food from the throat to the stomach, is situated behind the trachea and in front of the spine. It features two muscular rings: the upper esophageal sphincter, relaxing to allow food passage, and the lower esophageal sphincter, regulating food movement into the stomach and preventing stomach acid reflux. This latter sphincter resides at the gastroesophageal (GE) junction.

Primarily, esophageal cancer emerges from cells within the esophageal lining, progressing to affect outer layers and adjacent tissues. Though it can originate anywhere along the inner wall, two primary types exist: squamous cell carcinoma and adenocarcinoma.

  1. What are the risk factors for esophageal cancer?

Several factors can increase the risk of developing esophageal cancer, such as:

  1. Smoking: Tobacco use, including smoking cigarettes, cigars, or pipes, significantly increases the risk of esophageal cancer. The harmful chemicals in tobacco smoke can damage the cells lining the esophagus, leading to cancerous growth.

  2. Heavy Alcohol Consumption: Drinking alcohol excessively over a long period, especially hard liquor like whiskey or spirits, can irritate the esophagus and increase the risk of cancer. Heavy alcohol consumption often goes hand in hand with smoking, further elevating the risk.

  3. Obesity: Being overweight or obese is linked to a higher risk of developing esophageal cancer. Excess body fat, especially around the abdomen, can increase pressure on the stomach and cause acid reflux, a known risk factor for esophageal cancer.

  4. Acid Reflux (GERD): Gastroesophageal reflux disease (GERD) is a condition where stomach acid frequently flows back into the esophagus, causing irritation and inflammation. Chronic GERD can lead to changes in the lining of the esophagus, increasing the risk of cancer, particularly adenocarcinoma.

  5. Barrett's Esophagus: Barrett's esophagus is a condition where the cells lining the lower esophagus change due to repeated exposure to stomach acid from GERD. People with Barrett's esophagus have an increased risk of developing esophageal adenocarcinoma, a type of cancer.

  6. Diet Low in Fruits and Vegetables: A diet lacking in fruits and vegetables, which are rich in vitamins, minerals, and antioxidants, may contribute to the development of esophageal cancer. These nutrients help protect cells from damage and support overall health.

  7. Achalasia: Achalasia is a rare disorder of the esophagus that affects its ability to move food into the stomach. People with achalasia have a slightly higher risk of developing esophageal cancer compared to the general population.

  1. What are the symptoms of esophageal cancer?

Symptoms of esophageal cancer may include the following:

  1. Difficulty Swallowing (Dysphagia): Dysphagia is one of the most common symptoms of esophageal cancer, especially as the tumor grows larger and obstructs the passage of food and liquids through the esophagus. Initially, dysphagia may be mild and occur with solid foods, but it can progress to difficulty swallowing liquids as well.

  2. Persistent or Worsening Indigestion: Chronic indigestion, also known as heartburn or acid reflux, that doesn't improve with over-the-counter antacids or lifestyle changes may be a symptom of esophageal cancer, particularly if it's accompanied by other warning signs.

  3. Chest Pain or Pressure: Some people with esophageal cancer may experience chest pain or pressure, often behind the breastbone or sternum. This discomfort can be persistent and may worsen with swallowing or lying down.

  4. Unexplained Weight Loss: Significant and unintentional weight loss can occur in people with esophageal cancer, particularly as the disease progresses. This weight loss may be due to difficulty swallowing, reduced appetite, or the body's increased energy needs as it fights the cancer.

  5. Regurgitation: Regurgitation is the sensation of food or liquid coming back up into the throat or mouth, often accompanied by a bitter or sour taste. It may occur shortly after eating or when lying down, especially if the lower esophageal sphincter is weakened or compromised.

  6. Hoarseness or Chronic Cough: Esophageal cancer can sometimes cause irritation or compression of the nerves and structures in the chest, leading to hoarseness or a persistent cough. These symptoms may be due to the tumor pressing against the nearby trachea or vocal cords.

  7. Pain or Discomfort in the Throat or Back: Some people with esophageal cancer may experience pain or discomfort in the throat, neck, or upper back. This pain may be persistent and unrelated to eating or swallowing, and it may worsen over time as the tumor grows.

  8. Chronic Fatigue: Fatigue or weakness that doesn't improve with rest or sleep can be a symptom of advanced esophageal cancer. Cancer-related fatigue is often profound and can significantly impact a person's quality of life.

If you're feeling like something's not quite right, it's always best to trust your gut and get it checked out by a pro! Early detection of esophageal cancer means we can tackle it head-on and give you the best shot at kicking it to the curb.

  1. How is esophageal cancer diagnosed?

    When it comes to diagnosing esophageal cancer, doctors use a variety of methods to get the full picture. This can include physical exams, imaging tests like X-rays or CT scans, and sometimes even scoping procedures to take a closer look inside the esophagus. If needed, they may also perform a biopsy to collect tissue samples for further analysis.

  2. What are the treatment options for esophageal cancer?

When it comes to esophageal cancer treatment, there's no one-size-fits-all approach. Different options are available, each tailored to the individual's specific circumstances. Let's see some of the most common treatment methods according to JOHNS HOPKINS:

  1. Nutrition Therapy: Before diving into cancer treatment, some individuals may undergo special diets, supplements, or intravenous (IV) treatments to boost their body's strength.

  2. Radiation Therapy: This treatment uses X-rays, gamma rays, or charged particles to shrink tumors. A radiation oncologist plans personalized treatment to effectively target the tumor while minimizing damage to healthy tissue.

  3. Chemotherapy: Powerful drugs are used to kill cancer cells or prevent them from coming back. Often, chemotherapy is combined with radiation therapy, either before or after surgery, to improve outcomes.

  4. Surgery: Surgical removal of cancerous tissue in the esophagus and surrounding areas may be necessary. Various techniques, including transhiatal surgery, Ivor-Lewis surgery, minimally invasive esophagectomy (MIE), and robotic surgery, may be employed depending on the tumor's location and other factors.

  5. Supportive Services: In addition to primary treatments, supportive care is crucial for managing symptoms and enhancing quality of life. This may include physical therapy, mental health counseling, and pain management.

Now, let's talk about two key treatment modalities in more detail: radiation therapy and chemotherapy.

Radiation Therapy:

  • Radiation therapy targets cancerous tumors or lymph nodes using high-energy radiation beams. It's especially beneficial for esophageal cancer patients when used alongside other treatments.

  • The treatment is typically delivered daily over several weeks, with each session lasting about 15 minutes.

  • While side effects like nausea, tender skin, and fatigue are possible, healthcare teams work diligently to manage these symptoms and ensure patient comfort.


  • Chemotherapy employs powerful drugs to halt cancer cell growth and prevent recurrence. Often used in combination with other treatments, such as radiation therapy, chemotherapy plays a vital role in fighting esophageal cancer.

  • Patients may receive chemotherapy before or after surgery, or as part of neoadjuvant therapy to shrink tumors before surgical removal.

  • While side effects such as nausea, hair loss, and increased infection risk are common, supportive care measures are in place to alleviate discomfort and ensure patient well-being.

  1. Can esophageal cancer be prevented?

According to the American Cancer Society, while not all cases of esophageal cancer can be prevented, there are steps individuals can take to significantly reduce their risk of developing this disease. Here are some key strategies:

  1. Avoid Tobacco and Alcohol: In the United States, tobacco and alcohol use are the primary lifestyle risk factors for esophageal cancer. Both factors individually increase the risk of this cancer, and the risk is further elevated when they are combined. Steering clear of tobacco and alcohol is among the most effective ways to mitigate the risk of esophageal cancer.

  2. Maintain a Healthy Diet and Weight: Adopting a nutritious eating pattern and maintaining a healthy weight are crucial. A diet rich in fruits and vegetables may help lower the risk of esophageal cancer, while obesity, particularly in relation to adenocarcinoma, has been associated with increased risk. Regular physical activity may also contribute to reducing the risk of esophageal cancer.

  3. Address Reflux and Barrett's Esophagus: Treating reflux can help prevent Barrett's esophagus and subsequent esophageal cancer. Reflux management typically involves dietary and lifestyle modifications, weight management for overweight individuals, and medications such as H2 blockers or proton pump inhibitors (PPIs). In cases where reflux is not adequately controlled, surgery may be considered.

  4. Monitor High-Risk Individuals: Individuals at higher risk for esophageal cancer, such as those with Barrett's esophagus, often undergo regular endoscopies to detect any abnormal changes in the esophageal lining. If precancerous dysplasia is detected, interventions may be recommended to prevent progression to cancer.

It's worth noting that some studies suggest a potential protective effect against esophageal cancer among individuals with Barrett's esophagus who regularly take aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). However, the long-term use of these medications can pose risks such as kidney damage and gastrointestinal bleeding, so their use for esophageal cancer prevention should be carefully considered in consultation with a healthcare professional.

  1. What is the prognosis for esophageal cancer?

Prognosis refers to the expected long-term impact of a disease on an individual, and it varies based on several factors, including:

  • The location of the tumor within the body

  • Whether the cancer has metastasized (spread) to other organs

  • The extent of tumor removal achieved through surgery

Esophageal cancer survival rates are typically estimated based on historical outcomes among groups of patients with the disease. The overall five-year survival rate for esophageal cancer is approximately 20%, though individual survival rates may fall within a range of 5% to 47%.

Higher survival rates are typically observed in cases where esophageal cancer is detected early and when the tumor is small. Conversely, when the cancer is advanced or has metastasized, treatment becomes more challenging, resulting in lower five-year survival rates.

  1. Is esophageal cancer hereditary?

Certain gene mutations associated with esophageal cancer have been identified as hereditary, meaning they are passed down through families and occur in all cells of the body. However, these mutations are responsible for only a small percentage of esophageal cancer cases, and the associated risk cannot be entirely avoided. Some of the hereditary conditions linked to esophageal cancer include:

  1. Tylosis (Howel-Evans syndrome)

  2. Bloom syndrome

  3. Fanconi anemia

  4. Familial Barrett's esophagus

  1. How fast does esophageal cancer progress?

Esophageal cancer is often characterized by a slow-growing nature in its initial stages, meaning that it may develop over many years before symptoms become apparent. However, once symptoms do manifest, the cancer can progress rapidly. Therefore, early detection is crucial for effective treatment and improved outcomes.


After reading this newsletter, let's take a moment to address any potential concerns. If you've experienced any symptoms mentioned or have any worries about esophageal cancer, consider taking this short quiz. It can provide some insight and prompt further discussion with a healthcare professional if needed:

Esophageal Cancer Quiz

Remember, early detection and proactive communication with your doctor are crucial steps in managing your health effectively.

  1. Healthy Eating: A yummy recipe from our Frutti Chef

Good nutrition is essential for maintaining overall health and well-being. Whether you're facing health challenges or simply aiming to live your best life, making smart food choices can make a significant difference.

Our Frutti Chef has prepared a delightful recipe that's not only delicious but also packed with nutrients to fuel your body. Give it a try and let us know how you like it! Your feedback matters, and we hope this recipe brings joy and nourishment to your day.

  1. TFW FAM making an impact

Big shoutout to our incredible Tutti Fam for their outstanding efforts in raising awareness for Myeloma last Thursday! Your dedication, support, and engagement truly make a difference in spreading awareness and understanding about this important health issue. Together, we are making strides in educating others and promoting early detection.

Together we make a difference

As an awesome fam, we are committed to raising awareness about important health issues like esophageal cancer and supporting those affected by it. Through informative articles, engaging quizzes, and delicious recipes, we strive to keep our community informed and empowered to take charge of their health.

As we continue our journey of spreading awareness this month and beyond, we encourage you to join us in supporting each other and advocating for early detection and prevention. Together, we can make a difference in the fight against cancer and create a healthier, happier future for all.

Thank you for being part of our community and for your unwavering support. Until next time, stay bold, stay brave, stay beautiful & healthy!

Please note: The information provided in this newsletter is for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your qualified health provider with any questions you may have regarding a medical condition.

If you found this newsletter informative and valuable, please consider sharing it with your friends and family. You can also collect it for just 5 $MATIC, a contribution that goes directly to our donation wallet (0x83F371C97B80BD9BbA4330164F0Bf47E857577DC), supporting cancer warriors on their journey.

Collect this post to permanently own it.
TFW Talks Cancer logo
Subscribe to TFW Talks Cancer and never miss a post.
#esophageal cancer
  • Loading comments...